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Relburn is committed to developing innovative products to better
the lives of people with inflammatory disorders. The Company’s
lead programs are in NASH (nonalcoholic steatohepatitis) and gout.

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Chronic human illness commonly results from dysfunction in multiple physiologic pathways,
and discovery strategies based on concepts of “one-target, one-disease” are proving increas-
ingly unsuccessful. Metabolomics has driven an interest in agents that modulate multiple tar-
gets simultaneously. Targeting cellular function as a system, rather than at a single-target,
may lead to novel classes of effective multi-targeted drugs with fewer side-effects.*

*Paragraph adapted from Schrattenholz A, et al: Methods Mol Biol. 662:29-58, 2010.